Outcome in West syndrome.

OBJECTIVES To assess the seizure and developmental outcome in children with West syndrome with respect to treatment lag. METHODS Twenty-six children satisfying inclusion criteria of West syndrome i.e., infantile spasms, psychomotor retardation and abnormal EEG pattern were prospectively evaluated. Response to treatment was assessed based on seizure control, EEG, developmental assessment and parental observations. RESULTS The time lag from onset of seizures to appropriate treatment was <1 month in 11 children; 1-6 months in 8 children; and >6 months in 7 children. Children with treatment lag <1 month fared better than those who had a large treatment lag (P<0.05). Children with good seizure control also showed better developmental improvement (P<0.05). CONCLUSION Children with West syndrome have better seizure control and development, if the treatment is started within 1 month of onset of symptoms.